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Redwood City, Calif. — September 24, 2025 — Prenuvo, the leading whole-body MRI for proactive health screening, today announced a collaboration with Parsley Health, the functional medicine practice combining advanced diagnostics with a personalized, root-cause approach to care. The partnership officially launches Prenuvo’s offering to Parsley Health members as part of their clinical care, making proactive health insights more accessible and empowering members to take greater control of their long-term well-being.

Longevity and proactive health management aren’t just about adding years to life; they’re about helping ensure those years are lived with energy, clarity, and resilience. With rising rates of cancer, autoimmune disorders, and cardiovascular disease, the need for accessible functional health care that empowers people to take control of their long-term well-being has never been greater. Parsley Health, with centers in Los Angeles and New York City and nationwide telehealth services, addresses the root cause of symptoms through advanced diagnostic testing and comprehensive care programs.

Through its partnership with Prenuvo, Parsley Health is now expanding that model to include a comprehensive whole-body MRI screening. Members can use Prenuvo scans to help detect hundreds of conditions, including cancers, aneurysms, and neurological, liver, and kidney diseases, often before symptoms appear.

Once members opt in, Parsley Health’s care team facilitates the Prenuvo scan referral and handles the logistics, all with a seamless hand-off so patients can quickly schedule and prepare for their appointment. This integration lets members bring their scan results directly back to Parsley Health providers for ongoing guidance and long-term support.

“My Prenuvo scan gave me insights into my health that will serve me now and for decades to come. From adjusting how I weight train around Baker’s cysts in my knees that I learned I had, to tracking a benign kidney tumor that could need intervention in the future,” said Robin Berzin, MD, Founder and CEO of Parsley Health. “I also loved the experience. The space was beautiful, the staff was kind and supportive, and the fact that I could watch Netflix throughout my scan made me incredibly comfortable. We are at an inflection point in health where data, from wearables, to in-depth biomarker testing like what Parsley Health offers, to scans like Prenuvo, will change how we as individuals approach our health, and will bend the cost curve of healthcare.”

"Information is powerful, and knowing what to do with that information is empowerment,” said Andrew Lacy, Founder and CEO of Prenuvo. “This collaboration with Parsley Health brings together two powerful forces: Prenuvo’s ability to help reveal a comprehensive picture of your health in under an hour, and Parsley’s expertise in translating that knowledge into personalized, ongoing care. Together, we’re providing people with more clarity about their health with the goal that this knowledge can help them pursue longer, healthier lives”. 

About Prenuvo

Prenuvo makes proactive health screening seamless and more widely accessible. Combining advanced technology with radiation-free and non-invasive whole body scans, Prenuvo’s patient-centric design is optimized to assess the body holistically, providing individuals with a comprehensive overview of their health in under 60 minutes. Prenuvo’s exclusively-affiliated Radiology group partners consist of 100+ radiologists who help risk-stratify each patient report, keeping in mind healthcare complexities from the patient’s perspective, the treating clinician’s perspective, and the healthcare system’s perspective.

Prenuvo clinics are currently open in New York, Buffalo, Redwood City, Los Angeles, Pasadena, Irvine, Dallas, Houston, Boca Raton, Chicago, Las Vegas, Dallas, Hercules Research Center in Boston, Bethesda (DC metro area), Atlanta, Vancouver, and a partner location in Minneapolis. Learn more at www.prenuvo.com.

About Parsley Health

Parsley Health is a functional medicine practice redefining primary care with a personalized, root-cause approach to medicine. Parsley’s proprietary functional health protocols combine advanced diagnostics, nutrition, lifestyle guidance, and physician-led treatment plans to address chronic conditions such as autoimmune diseases, hormone imbalances, digestive issues, and metabolic dysfunction. Parsley Health’s care is delivered through a digital-first platform that is available nationwide, with centers in New York City and Los Angeles, and covered by many major insurers. Learn more at www.parsleyhealth.com.

Press Contact:

Christine Alabastro

prenuvo@vsc.co

AI-powered MRI study finds link between smoking and early signs of brain aging in 10,000+ healthy adults

Redwood City, CA — [July 23] — Prenuvo, the leading whole body MRI for proactive health screening, today announced its research has been published in Nature Partner Journal – Dementia (npj-Dementia). The research reveals a strong association between cigarette smoking and brain atrophy in a cohort of 10,134 healthy adults scanned using Prenuvo’s full-body MRI platform. Led by Dr. Somayeh Meysami, MD, Assistant Professor of Neurosciences at Saint John’s Cancer Institute and Clinical Research Scientist at the Pacific Brain Health Center, Pacific Neuroscience Institute (PNI), the study utilized advanced structural MRI and deep learning segmentation to show how smoking is linked to regions of the brain commonly affected in Alzheimer’s disease.

The full list of collaborators include: Somayeh Meysami, Saurabh Garg, Sam Hashemi, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Rajpaul Attariwala, Kellyann Niotis, David A. Merrill, and Cyrus A. Raji.

The research found that individuals with any history of smoking (measured by pack-years) had notably lower gray and white matter volumes compared to non-smokers. Greater cumulative exposure (more pack-years) significantly predicted volume reductions in key brain regions, including the temporal lobe, parietal lobe, hippocampus, precuneus, and posterior cingulate. The analysis also highlighted body mass index (BMI) as a contributing factor, suggesting that higher BMI may amplify the negative impact of smoking on brain structure.

“Our results clearly show that smoking significantly impacts brain health by its link to increased brain atrophy in areas critical to cognitive function,” said Dr. Somayeh Meysami, MD, lead author of the study. “These findings reinforce the urgent need for preventive measures addressing both smoking cessation and healthy weight management.”

Senior author Cyrus A. Raji, MD, PhD, Associate Professor of Radiology at Washington University in St. Louis added, “This work underscores the interconnected nature of lifestyle factors like smoking and obesity in accelerating brain aging. Understanding these relationships provides an essential foundation for developing targeted strategies aimed at preventing dementia and preserving cognitive health.”

The study’s design, utilizing a large sample size and sophisticated neuroimaging, makes a significant contribution to public health by identifying modifiable risk factors for cognitive decline and dementia. Future research will further explore how interventions targeting smoking and BMI might mitigate or even reverse these adverse effects.

“This is exactly the kind of insight that wasn’t measurable before. By combining high-fidelity imaging with the largest dataset of healthy brain scans and intelligent, accurate, and reproducible measurement of small brain structure using AI, we’re now able to quantify subtle but critical effects – like smoking-induced brain atrophy – with unprecedented clarity,” said Sam Hashemi, Vice President of Artificial Intelligence & Research at Prenuvo. “It’s a window into what becomes possible when AI meets population-scale precision imaging, opening the door to earlier detection, targeted prevention, and a deeper understanding of cognitive aging.” 

For more information on the study, read the whole study here.

About Prenuvo

Prenuvo makes MRI scanning for early detection of many types of cancer and many other diseases seamless and more widely accessible. Combining cutting-edge analysis technology with radiation-free and non-invasive whole body scans, Prenuvo’s patient-centric design is optimized to assess the body holistically and in under 60 minutes, compared with the several hours it would take to achieve this level of insight from conventional MRI scans. Prenuvo’s team of 100+ radiologists specializes in whole body MRI screenings to risk-stratify each patient report, keeping in mind healthcare complexities from the patient’s perspective, the treating clinician’s perspective, and the healthcare system’s perspective.

Media Contact: 

Christine Alabastro

prenuvo@vsc.co

Groundbreaking research using Prenuvo whole body MRI data earns the Alzheimer Award, awarded to Dr. Cyrus Raji by the Journal of Alzheimer’s Disease

SAN FRANCISCO — July 8, 2025 — Prenuvo, the leading whole body MRI for proactive health screening, today announced research powered by its imaging dataset has received the prestigious 2025 Alzheimer Award from the Journal of Alzheimer’s Disease (JAD). The award, granted for the last 25 years, honors one of the most impactful studies advancing the field of Alzheimer’s research in the past year and was selected by the international JAD Editorial board out of 800 submissions. 

The awarded study, “Exercise-Related Physical Activity Relates to Brain Volumes in 10,125 Individuals,” found that just 25 minutes of moderate to vigorous physical activity per week is linked to greater brain volume in regions vulnerable to Alzheimer’s, supporting exercise as a preventive strategy for dementia. The study used Prenuvo’s extensive normative dataset of proactive whole body MRI scans to identify structural brain changes in asymptomatic individuals that may precede clinical signs of Alzheimer’s. The study marks a significant step toward earlier, noninvasive detection of the neurodegenerative disease.

The full list of collaborators includes: Cyrus A. Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Thanh Duc Nguyen, Ahmed Gouda, Yosef Gavriel Chodakiewitz, and Rajpaul Attariwala.

“Our findings suggest that subtle brain structure changes linked to Alzheimer’s may be detectable earlier than previously believed, especially with access to high-resolution imaging and AI tools that can segment and analyze these small structures at scale,” said lead study author Dr. Cyrus Raji, PhD, Mallinckrodt Institute of Radiology, Washington University in St. Louis. “This research was facilitated by Prenuvo’s unique MRI dataset, which combines whole body imaging with high spatial resolution, enabling a precise level of structural detail.”

While traditional Alzheimer's diagnostics rely on PET scans and cerebrospinal fluid analysis, this study highlights how non-invasive, whole body MRI, paired with advanced analysis using AI, can reveal early indicators of cognitive decline in large, diverse populations. Prenuvo's anonymized imaging data allowed researchers to examine the structural brain correlates of Alzheimer’s in people without clinical symptoms, helping to push the field of early detection forward.

“Imaging-driven research can unlock earlier, more accessible ways to detect neurodegenerative disease,” said Sam Hashemi, Vice President of AI and Research at Prenuvo and study co-author. “This award underscores the potential of not just Prenuvo, but when proactive imaging using MRI and AI come together, they can reveal hidden signals in the brain that might otherwise go undetected. It points to a world where insights like these become part of routine care, not just research.”

The Journal of Alzheimer’s Disease gives the Alzheimer Award annually to a lead author whose paper has significantly advanced Alzheimer’s research. The award includes a bronze medal featuring Alois Alzheimer and a $7,500 honorarium to be presented at the Alzheimer’s Association International Conference in Toronto, Canada from July 27-31st, 2025.

The full paper is available here: https://journals.sagepub.com/doi/10.3233/JAD-230740 

About Prenuvo:

Prenuvo makes MRI scanning for early detection of many types of cancer and many other diseases seamless and more widely accessible. Combining cutting-edge analysis technology with radiation-free and non-invasive whole body scans, Prenuvo’s patient-centric design is optimized to assess the body holistically and in under 60 minutes, compared with the several hours it would take to achieve this level of insight from conventional MRI scans. Prenuvo’s team of 100+ radiologists specializes in whole body MRI screenings to risk-stratify each patient report, keeping in mind healthcare complexities from the patient’s perspective, the treating clinician’s perspective, and the healthcare system’s perspective.

Media Contact: 

Christine Alabastro

prenuvo@vsc.co

‍

At Prenuvo, we believe that answers to today’s most pressing health challenges are already inside us, if we know where to look. Using our proprietary dataset, which is the largest collection of whole-body MRI scans in primarily asymptomatic individuals in the world, our in-house AI research team and research partners are releasing two new studies that explore how everyday habits leave structural footprints in our bodies and brains.

Both studies have been presented at the 2025 ISMRM Annual Meeting (International Society of Magnetic Resonance).

Here’s what we found:

1. Just 2 drinks a day? Your brain and organs already know

While much of the research out there on alcohol focuses on those with alcohol use disorder, this study looked at people who drink moderately (two or more drinks a day) and found that even without clinical addiction, the effects are measurable and systemic.

In a study of over 1,100 people with no diagnosis of alcohol use disorder, moderate drinkers showed:

• Loss of brain volume in regions tied to memory, motor control, and decision-making
• Liver volumes 10% larger than non-drinkers
• Visceral fat levels 15.6% higher than non-drinkers
  

The most surprising part? Changes in organ size were independently linked to brain atrophy, suggesting that alcohol’s effects aren’t siloed; they ripple across systems. This points to a broader, systemic toll that moderate drinking may take on long-term brain health. Learn more: link to full study.

Research participants:

1. Vigilance Health Imaging Network, Vancouver, Canada
2. Prenuvo Inc, Vancouver, Canada
3. Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA
4. Saint John’s Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, USA
5. Washington University School of Medicine in St Louis, Mallinckrodt Institute of Radiology and Department of Neurology, St. Louis, MO, USA

2. Depression reduces brain volume, but exercise may help reverse it

Exercise is widely recommended to improve physical and mental health, but what’s actually happening in the brain when we move our bodies? A large-scale AI-assisted MRI study of 6,458 individuals (1,579 with depression) showed that individuals with depression had significantly smaller brain volumes than those without. However, among those who did exercise, some of that volume was preserved or even increased.

In depressed individuals, exercise was most strongly linked to brain growth in:

• Medial orbitofrontal cortex: Involved in reward, emotion, and decision-making; more volume here may help regulate mood and motivation.
• Lingual cortex: Associated with visual memory and emotional processing.
• Rostral middle frontal cortex and middle temporal cortex: Critical for attention, social reasoning, and interpreting emotional cues.

In non-depressed individuals, exercise showed the greatest impact on:

• Thalamus: The brain’s “relay center” that helps route information between regions.
• Fusiform cortex: Important for facial recognition and visual memory.
• Cerebellum: Known for motor control, but also increasingly recognized for its role in mood and cognition.

This suggests that not only can exercise mitigate the structural brain impacts of depression, but the brain responds differently depending on mental health history. It's a powerful clue in understanding how, and for whom, lifestyle interventions might have the greatest neuroprotective impact. Learn more: link to full study.

Research participants:

1. Vigilance Health Imaging Network, Vancouver, Canada
2. Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA
3. Saint John’s Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, USA
4. Prenuvo Inc, Vancouver, Canada
5. Washington University School of Medicine in St Louis, Mallinckrodt Institute of Radiology, St. Louis, MO, USA
6. Department of Neurology, Washington University in St. Louis, MO, USA
7. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA

What's next?

Our imaging data is fueling a new wave of AI-powered research across brain health, cancer, internal medicine, and more.

So far, our work has led to 30+ presentations and papers at major conferences like RSNA and AACR. One of our studies on brain volume loss was even named the most-read article of 2023 in the Journal of Aging and Disease.

We’re continuing to partner with leading academic institutions to explore big questions in human health, and we’re doing it with the kind of data that’s never been available at this scale before.

REDWOOD CITY, CA (April 7, 2025) – Prenuvo, the leader in proactive whole-body MRI screening, today announced the opening of its first clinic in Las Vegas, marking its first entry in Nevada.  

The new Prenuvo clinic at 350 S Rampart Blvd will provide residents with radiation-free, non-invasive, whole-body MRI scans designed to detect cancers, aneurysms, and hundreds of health conditions before symptoms appear. Each scan takes less than an hour, providing a comprehensive, holistic view of the body. 

“We’re thrilled to join the Las Vegas community and offer residents a powerful tool to stay ahead of their health,” said Andrew Lacy, Founder and CEO of Prenuvo. “Our goal is to make preventative healthcare as routine as a yearly check-up, and we are excited to bring this technology to the Las Vegas community.”

The Prenuvo mission is already changing lives. After her mother died unexpectedly from a heart attack, Sagan, a wife and mother of two, opted for a Prenuvo scan. The MRI showed Sagan had a brain aneurysm. With these results, she was able to contact her healthcare provider and schedule life-saving surgery. Sagan credits Prenuvo with saving her life. “It's so important for people to understand that it's not a scan just for you. It gave my kids a mom,” said Saagan.

Las Vegas is one of the fastest-growing metropolitan areas in the United States, home to over 660,000 residents, with 61% between the ages of 18 and 64, according to the census reporter. As the city continues to expand and evolve, so does its approach to health. More residents are seeking tools that support longevity, independence, and early detection of potential health issues. Prenuvo is opening its doors to empower the growing Las Vegas community with an accessible, proactive solution to manage their long-term health so people can keep showing up for the careers, families, and lives they love.

‍About Prenuvo: 

Prenuvo makes MRI scanning for early detection of cancer, “silent killers” like aneurysms, and other diseases seamless and more widely accessible. Combining cutting-edge quantification and analysis technology with radiation-free and non-invasive full-body scans, Prenuvo’s patient-centric design is optimized to assess the body holistically and in under 60 minutes, compared with the 4-5 hours it would take to achieve this level of insight from conventional MRI scans.

Prenuvo clinics are currently open in New York, Buffalo, Redwood City, Los Angeles, Dallas, Houston, Boca Raton, Chicago, Hercules Research Center in Boston, Bethesda (DC metro area), Atlanta, Vancouver, and a partner location in Minneapolis.

‍Media Contact

Christine Alabastro

media@prenuvo.com

‍

REDWOOD CITY, Calif.--(BUSINESS WIRE)--Prenuvo, the leader in proactive whole-body MRI screening, today disclosed that it quietly raised $120M as part of Series B fundraising during 2024, demonstrating its category leadership in preventative health. The company has identified over 1.4 million personalized health insights across its member base, highlighting the critical role of early detection. This milestone comes as Prenuvo surpassed 110,000 members and secured FDA clearance for its AI-powered Prenuvo Body Composition report.

“Prenuvo is leading a movement to make proactive healthcare accessible and transformative for everyone,” said Andrew Lacy, CEO of Prenuvo Inc. “We’re introducing a new approach to early detection that empowers individuals to take control of their health before symptoms emerge. This isn’t just about healthcare; it’s about reimagining how we approach health, using cutting-edge technology and world-class expertise to prevent disease and help people live longer, healthier lives.”

The round, co-led by Forerunner Ventures, Left Lane Capital, and existing investor Felicis, has accelerated Prenuvo’s augmentation of its core industry-leading whole-body MRI screening with additional modalities and analyses of the human body.

Innovative Product Expansion

Prenuvo today announced FDA clearance for its AI-powered Prenuvo Body Composition report, marking a significant milestone in the company’s growth. Building on this momentum, Prenuvo introduces three major advances:

• FDA-cleared, AI-powered whole-body composition analysis platform that is non-invasive and delivers precise, actionable, and quantitative data on visceral fat, subcutaneous fat, liver fat, muscle volumes, as well as the volume of vital abdominal organs – providing patients with a personalized report to make informed lifestyle choices and proactive health decisions.
• Groundbreaking new brain health scan that equips patients with critical data on brain function, cognitive health, and early indicators of neurodegenerative conditions.
• Comprehensive functional and conventional blood bio-marker assessment that uses a custom built panel of blood tests to provide insights into metabolic, cardiovascular, hormonal, and immune health. Designed to work symbiotically with imaging to deepen health insights.

These new capabilities will launch immediately in a bundled offering called Prenuvo Enhanced in Silicon Valley, Los Angeles and New York locations, with other locations offering these enhanced screenings in the spring. To sign up for a waitlisted location, visit https://prenuvo.com/enhanced-screening

“Last year demonstrated an unmistakable shift in consumer behavior towards proactive health management,” said Sundeep Peechu, Managing Partner at Felicis. “Prenuvo has a unique integrated model that is difficult to replicate, and their advanced screening positions them to lead this transformation in preventative healthcare.”

Deliberate Growth and Clinical Excellence

Prenuvo has built the world’s largest private radiology group focused solely on whole-body MRI, with over 80 board-certified radiologists. This expertise has driven research collaborations with premier academic centers studying health, aging, and disease through the unique combination of MRI and AI.

Unlike others who outsource both imaging and radiology services, Prenuvo is fully vertically integrated, owning and operating 17 dedicated centers across North America. With a growing movement to prioritize preventative healthcare, Prenuvo will bring its revolutionary approach to 15 more clinics, including Europe and Australia, marking its first international expansion outside of North America.

“With only 2.5% of healthcare spending focused on preventative medicine, the US system waits for people to become sick before intervening,” said Brian O’Malley from Forerunner. “Consumers have grown tired of this and are responding with their own wallets. Prenuvo is the preeminent solution for a comprehensive understanding of one’s health, giving today’s patients unprecedented levels of knowledge to not just understand, but proactively intervene in the challenges that arise as we all age. Longevity is the new luxury and Prenuvo is democratizing access so that more can benefit from this.”

“Prenuvo has empowered patients in ways that conventional medical care simply hasn’t. Consumers are taking ownership and seeking answers outside of the traditional healthcare system. The physician and clinical ecosystem is waking up to the needs and wants of their patients, who are increasingly demanding proactive and preventative healthcare solutions like Prenuvo,” says Harley Miller, Managing Partner & CEO, Left Lane Capital. “We look forward to seeing how the team continues to scale, advance their proprietary research, and build on their life-changing (and saving) technology.”

About Prenuvo

Prenuvo makes MRI scanning for early detection of many types of cancer, “silent killers” like aneurysms, and other diseases seamless and more widely accessible. Combining cutting-edge analysis technology with radiation-free and non-invasive full-body scans, Prenuvo’s patient-centric design is optimized to assess the body holistically and in under 60 minutes, compared with the several hours it would take to achieve this level of insight from conventional MRI scans. Prenuvo, Inc. is the administrative and managerial services company for the affiliated Prenuvo physician-owned professional corporations that deliver medical services in-office and virtually. Prenuvo Inc. and the Prenuvo medical entities do business under the “Prenuvo” brand.

Prenuvo is backed by leading venture capital firms and investors in health, fitness and category-defining consumer brands such as Felicis [investors in Fitbit (IPO), Guardant Health (IPO) and Ring (acq. by Amazon)], 23AndMe CEO Anne Wojcicki, Nest founder Tony Fadell, Eric Schmidt, Cindy Crawford and Lasker award recipient Dr. Timothy A. Springer.

About Forerunner

Forerunner is a venture capital firm investing at the intersection of shifting consumer behavior and emerging, transformative technology. Founded in 2012, Forerunner has raised nearly $3 billion in assets under management, and is an early investor in, Chime, Faire, OURA, Hims & Hers, The Farmer’s Dog, Ritual, Headway, Prenuvo, Fora, Glossier, and more.

About Left Lane Capital

Founded in 2019, Left Lane Capital is a New York and London-based global venture capital and growth equity firm investing in hyper-growth consumer and SMB businesses with enduring customer relationships. Left Lane's mission is to partner with extraordinary entrepreneurs who create category-defining companies across growth sectors of the economy. Select investments include Talkiatry, Evvy, Pearl, Wayflyer, M1 Finance, Bilt Rewards, Blank Street, Kings League, Olipop, and more.

For more information, visit leftlane.com.

About Felicis

Founded in 2006, Felicis is a venture capital firm investing in companies reinventing core markets, as well as those creating frontier technologies. Felicis focuses on early-stage investments and currently manages over $3B in capital across 9 funds. The firm is an early backer of more than 50 companies valued at $1B+. More than 100 of its portfolio companies have been acquired or gone public, including Adyen (IPO), Credit Karma (acq by Intuit), Cruise (acq by General Motors), Fitbit (IPO), Guardant Health (IPO), Meraki (acq by Cisco), Ring (acq by Amazon), and Shopify (IPO). The firm is based in Menlo Park and San Francisco in California. Learn more at felicis.com.

Contacts

Media Contact:
Christine Alabastro
media@prenuvo.com